Publications

Deletion of Cacna1c (CaV1.2) in D1-expressing cells elicits divergent sex-specific effects on aversive and spatial memories. Preprint
Walsh JD, Scala-Chavez Diego, Lee AS, Martínez-Rivera A, Rajadhyaksha AM
bioRxiv | 2025 | 10.1101/2025.10.31.684545.
 

L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats
Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA.
Neuroscience | 2025 | doi: 10.1016/j.neuroscience.2025.01.003
 

Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity
Lee AS, Arefin TM, Stephen DN, Liu Y, Lao Z, Krishnamurthy A, De Marco García NV, Heck DH, Zhang J, Rajadhyaksha AM, Joyner AL.
Nature Communications | 2025 | doi: 10.1038/s41467-025-57080-6
 

Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia 
Martínez-Rivera A, Fetcho RN, Birmingham L, Jiu JX, Yang R, Foord C, Scala-Chávez D, Mekawy N, Pleil K, Pickel VM, Liston C, Castorena CM, Levitz J, Pan YX, Briand LA, Rajadhyaksha AM, Lee FS 
Science Advances | 2024 | doi: 10.1101/2024.04.02.585967
 

Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism 
Lin S, Gade AR, Wang HG, Niemeyer JE, Galante A, DiStefano I, Towers P, Nunez J, Schwartz TH, Rajadhyaksha AM, Pitt GS 
eLife |  2025 | doi: 10.7554/eLife.98661
 

A genetically encoded actuator selectively boosts L-type calcium channel in diverse physiological settings 
Del Rivero Morfin PJ, Chavez DS, Jayaraman S, Yang L, Kochiss AL, Colecraft HM, Liu XS, Marx SO, Rajadhyaksha AM, Ben-Johny M 
Science Advances | 2024 | doi: 10.1126/sciadv.adq3374
 

L-type calcium channel regulation of depression anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure
Nunes EJ, Kebede N, Rajadhyaksha AM, Addy NA 
Neuropharmacology | 2024 | doi: 10.1016/j.neuropharm.2024.110031
 

Repeat investigation during social preference behavior is suppressed in male mice with prefrontal cortex canca1c (Cav1.2) -deficiency through dysregulation of neural dynamics. Preprint
Hackett J, Nadkarni V, Singh RS, Carthy CL, Antigua S, Hall BS, Rajadhyaksha AM 
bioRxiv | 2023 | doi: 10.1101/2023.06.24.546368
 

L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development
Baker MR, Lee AS, Rajadhyaksha AM
Channels (Austin) | 2023 | doi: 10.1080/19336950.2023.217698
 

Regulation of social interaction by a frontostriatal circuit encoding hierarchical relationships 
Fetcho RN, Hall BS, Estrin D, Walsh AP, Schuette P, Kaminsky J, Singh A, Roshgadol J, Bavley CC, Nadkarni V, Antigua S, Huynh TN, Grosenick L, Carthy C, Komer L, Adhikari A, Lee FS, Rajadhyaksha AM, Liston C
Nature Communications | 2023 | doi: 10.1038/s41467-023-37460-6
 

Cav1.3 L-type Ca2+ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference 
Martínez-Rivera A, Hao J, Rice RC, Inturrisi CE, Rajadhyaksha AM
Neuropharmacology | 2023 | doi: 10.1016/j.neuropharm.2022.109368
 

Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors
Wang HG, Bavley CC, Li A, Jones RM, Hackett J, Bayleyen Y, Lee F, Rajadhyaksha AM, Pitt GS
JCI Insight | 2021 | doi: 10.1172/jci.insight.150698
 

Dual-process brain mitochondria isolation preserves function and clarifies protein composition 
Noterman MF, Chaubey K, Lin-Rahardja K, Rajadhyaksha AM, Pieper AA, Taylor EB
Proceedings of the National Academy of Sciences (PNAS) | 2021 | doi: 10.1073/pnas.2019046118
 

Loss of Cav1.2 channels impairs hippocampal theta burst stimulation-induced long-term potentiation 
Sridharan PS, Lu Y, Rice RC, Pieper AA,Rajadhyaksha AM
Channels | 2020 | doi: 10.1080/19336950.2020.1807851
 

Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference 
Burgdorf CE, Bavley CC, Fischer DK, Walsh A, Martinez-Rivera A, Hackett JE, Zallar LJ, Ireton KE, Hofmann F, Hell JW, Huganir RL, Rajadhyaksha AM
Neuropsychopharmacology | 2020 | doi: 10.1038/s41386-019-0597-z
 

Dopamine D1R-neuron cacna1c deficiency: a new model of remote fear in post-traumatic stress 
Bavley CC, Kabir ZD, Walsh A, Kosovsky M, Hackett J, Sun H, Vázquez-Rosa E, Cintrón-Pérez CJ, Miller E, Koh Y, Pieper AA, Rajadhyaksha AM
Molecular Psychiatry (Nature) | 2020 | doi: 10.1038/s41380-020-0730-8
 

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice 
Burgdorf CE, Jing D, Yang R, Huang C, Hill MN, Mackie K, Milner TA, Pickel VM2, Lee FS, Rajadhyaksha AM
Science Advances | 2020 | doi: 10.1126/sciadv. aay1502
> Featured by Weill Cornell Medicine Newsroom (2020) and The Science Breaker (2020)
 

Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels 
Bavley CC, Fetcho RN, Burgdorf CE, Fischer DK, Hall BS, Sayles N, Walsh A, Hackett J, Antigua S, Kash TL, Milner TA, Liston C, Rajadhyaksha AM 
Molecular Psychiatry (Nature) | 2020 | doi: 10.1038/s41380-019-0513-2
 

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α 
Kabir ZD, Che A, Fischer DK, Rice RC, Rizzo BK, Byrne M, Glass MJ, De Marco Garcia NV, Rajadhyaksha AM
Molecular Psychiatry (Nature) | 2017 | doi: 10.1038/mp.2017.124
> Featured by Weill Cornell Medicine Newsroom (2017), Cornell Chronicle (2017), and Medical Press (2017)